Stephan Lab

Creating more effective methods to harness the antitumor activity of immune cells


Howell F. Moffett, Michael E. Coon, Stefan Radtke, Sirkka B. Stephan, Laura McKnight. Abigail Lambert, Barry L. Stoddard, Hans-Peter Kiem & Matthias T. Stephan. Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers. Nature Communications.  8, Article number: 389 (2017).

Tyrel T. Smith, Sirkka B. Stephan, Howell F. Moffett, Laura E. McKnight, Weihang Ji, Diana Reiman, Emmy Bonagofski, Martin E. Wohlfahrt, Smitha P. S. Pillai & Matthias T. Stephan. In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers. Nature Nanotechnology. 2017 Aug: 813-820.

Smith TT, Moffett HF, Stephan SB, Opel CF, Dumigan AG, Jiang X, Pillarisetty VG, Pillai SPS, Wittrup KD, Stephan MT. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumor. Journal of Clinical Investigation. 2017 Jun 1;127(6):2176-2191.


Sirkka B. Stephan, Alexandria M. Taber, Ilona Jileaeva, Ericka P. Pegues, Charles L. Sentman and Matthias T. Stephan. Biopolymer implants enhance the efficacy of adoptive T cell therapy. Nature Biotechnology. 33, 97-101 (2015).



Matthias T. Stephan, Straight Shooters: Peptibodies Takes Aim.

Sci Transl Med 11 June 2014: Vol. 6, Issue 240, p. 240ec102

(Editor’s Choice article on Qin et al., Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice. Nature Medicine. published online 25 May 2014).


Matthias T. Stephan, Carbon Nanotubes Are Picky Hitchhikers.

Sci Transl Med 30 April 2014: Vol. 6, Issue 234, p. 234ec77

(Editor’s Choice article on B. R. Smith et al., Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Nat. Nanotechnol., published online 13 April 2014).