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Stephan, Chibawanye I. Ene, Tyrel T. Smith, Eric C. Holland and Matthias T. Stephan. Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies. Cancer Research. July 2018. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1530563371535-C0MX1MU4EHWYI4KVR6JB/Screen+Shot+2018-07-02+at+1.29.02+PM.png Publications Attack of the killer clones. The next generation of modified T-cell therapies is taking on solid tumors - but it's an uphill fight. 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Prof. Stephan receives the National Science Foundation CAREER Award. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1420840410530-BIEOOW8GUSWDNAEPA9JE/image-asset.gif News https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1396468531962-T7NA3JONBIN1SKNTKPIX/image-asset.png News https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1394609663955-1Z3I307RZUZK9P8TN3TW/image-asset.jpeg News March 12, 2014. Dr. Stephan was elected to serve as Associate Scientific Advisors for Science’s sister journal, Science Translational Medicine. http://stm.sciencemag.org/site/about/assoc_advisors.xhtml Science Translational Medicine invited members of the Advisory Board and principal investigators from Clinical and Translational Science Awards (CTSA) recipient institutions to nominate outstanding early-career translational scientists to serve as Associate Scientific Advisors for the journal. From this collection of nominees, the journal editors selected 26 Associate Advisors. With this program, Science Translational Medicine seeks to build connections with the community of trainees in translational medicine. In addition to acting as research advisors for Science Translational Medicine, these scientists will scan selected journals and choose and summarize research papers to be highlighted in the Editors' Choice section. Each Associate Advisor will have 8 to 10 of their articles appear in Science Translational Medicine over the next year. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1392065211186-NY026U78C3MMI4IX50B8/Nature+SciCafe.jpg News November 7, 2013. The Stephan lab was invited to present their work on biomaterial-supported T-cell implants at the Nature Scicafe event in San Francisco. This exclusive scientific forum that operates on an invitation-only basis and is hosted by the editors of Nature Biotechnology and Nature Medicine. This event provides the participating scientists with new connections and insight from the business audience regarding the potential commercialization of their work. http://stephanlab-fhcrc.squarespace.com/positions-available daily 0.75 2014-11-21 http://stephanlab-fhcrc.squarespace.com/research-projects daily 1.0 2026-08-20 https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/dc0669e6-e2b4-4347-bde2-ea13a179ba57/Screenshot+2026-08-20+at+10.26.00%E2%80%AFAM.png Contribution to Science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/45ea6647-5ea3-4653-854a-93630cad3cb3/Screenshot+2026-02-17+at+10.58.31%E2%80%AFAM.png Contribution to Science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/f50d0ae4-6d77-475a-a1cc-c58714dd298b/Screenshot+2026-02-17+at+11.03.42%E2%80%AFAM.png Contribution to Science - Make it stand out Schematic illustrating the envisioned clinical workflow for rectally applying gene therapy foam in patients with locally advanced rectal cancer https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/5c6d84e5-dfea-4643-81d9-e71bb450412d/Screen+Shot+2024-05-28+at+4.29.00+PM.png Contribution to Science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/3aff8574-805e-4b25-baeb-3e07e4276fb2/Screen+Shot+2024-06-17+at+11.08.52+AM.png Contribution to Science - Make it stand out Schematic illustrating how a rationally designed biomaterial implant can recruit, genetically reprogram, expand and release host tumor-infiltrating lymphocytes (TILs). We functionalized a porous collagen matrix with a lymphocyte chemoattractant, a vector encoding a tumor-specific Chimeric Antigen Receptor (CAR), and stimulatory anti-CD3/CD28 antibodies. Following implantation, these scaffolds effectively recruit host T cells, equip them with tumor recognizing receptors, rapidly expand and release them into the surrounding tumor tissue. https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1595630892292-HJAGEB8KF84354J3VHPV/Health+Innovation+of+the+year.png Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1576197495629-ARI91TUWBVFNMC8UQ9D4/Screen+Shot+2019-12-12+at+4.37.48+PM.png Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1576197308408-C24X0M7POI99XW92AN8L/Screen+Shot+2019-12-12+at+4.34.36+PM.png Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1580515250340-AQWVOOIH7K4S59BNYP50/FHCRC_CellDerivedVesicles-patient_20200131.jpg Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1610662666675-95QAXKHPFT98BP9IVT5U/Screen+Shot+2021-01-14+at+2.17.21+PM.png Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1576198169901-3XGVCAYOFLMICD6LG1BS/Screen+Shot+2019-12-12+at+4.48.28+PM.png Contribution to Science https://images.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1576198417234-URUUDU5UIWWIP0YXYYG9/Screen+Shot+2019-12-12+at+4.53.15+PM.png Contribution to Science https://video.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1bb272cf-51c6-418c-bb8c-d9aef427c8cc/playlist.m3u8 https://video.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/1bb272cf-51c6-418c-bb8c-d9aef427c8cc/thumbnail Contribution to Science Workflow of generating CAR-programming gene therapy foam. A syringe filled with foam precursor solution containing CAR-programming vector (viral- or nonviral), anti-CD3/CD28 antibodies and IL-2 is connected to a second syringe filled with air. The air and foam precursor are mixed vigorously drawing the syringe plungers back and forth, creating a uniform microfoam. PBMC concentrate is then externally added to gene therapy foam by gentle syringe mixing. https://video.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/445277c6-fccd-48b9-b592-8f1c080d62ac/playlist.m3u8 https://video.squarespace-cdn.com/content/v1/52de3742e4b0fc4c92c97d76/445277c6-fccd-48b9-b592-8f1c080d62ac/thumbnail Contribution to Science Contribution to Science