Stephan Lab

Creating more effective methods to harness the antitumor activity of immune cells

nature-communications.jpg

Howell F. Moffett, Michael E. Coon, Stefan Radtke, Sirkka B. Stephan, Laura McKnight. Abigail Lambert, Barry L. Stoddard, Hans-Peter Kiem & Matthias T. Stephan. Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers. Nature Communications.  8, Article number: 389 (2017). 

http://rdcu.be/vpnP

Tyrel T. Smith, Sirkka B. Stephan, Howell F. Moffett, Laura E. McKnight, Weihang Ji, Diana Reiman, Emmy Bonagofski, Martin E. Wohlfahrt, Smitha P. S. Pillai & Matthias T. Stephan. In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers. Nature Nanotechnology. 2017 Aug: 813-820.

http://www.nature.com/nnano/journal/v12/n8/full/nnano.2017.57.html

Smith TT, Moffett HF, Stephan SB, Opel CF, Dumigan AG, Jiang X, Pillarisetty VG, Pillai SPS, Wittrup KD, Stephan MT. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumor. Journal of Clinical Investigation. 2017 Jun 1;127(6):2176-2191.

http://www.jci.org/articles/view/87624.html

 

Sirkka B. Stephan, Alexandria M. Taber, Ilona Jileaeva, Ericka P. Pegues, Charles L. Sentman and Matthias T. Stephan. Biopolymer implants enhance the efficacy of adoptive T cell therapy. Nature Biotechnology. 33, 97-101 (2015).

http://www.nature.com/nbt/journal/v33/n1/full/nbt.3104.html

 

 

Matthias T. Stephan, Straight Shooters: Peptibodies Takes Aim.

Sci Transl Med 11 June 2014: Vol. 6, Issue 240, p. 240ec102

http://stm.sciencemag.org/content/6/240/240ec102

(Editor’s Choice article on Qin et al., Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice. Nature Medicine. published online 25 May 2014).

 

Matthias T. Stephan, Carbon Nanotubes Are Picky Hitchhikers.

Sci Transl Med 30 April 2014: Vol. 6, Issue 234, p. 234ec77

http://stm.sciencemag.org/content/6/234/234ec77

(Editor’s Choice article on B. R. Smith et al., Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Nat. Nanotechnol., published online 13 April 2014).


.